Theoretical Search for RNA Folding Nuclei
نویسندگان
چکیده
منابع مشابه
Theoretical Search for RNA Folding Nuclei
The functions of RNA molecules are defined by their spatial structure, whose folding is regulated by numerous factors making RNA very similar to proteins. Prediction of RNA folding nuclei gives the possibility to take a fresh look at the problems of the multiple folding pathways of RNA molecules and RNA stability. The algorithm previously developed for prediction of protein folding nuclei has b...
متن کاملSearch for folding nuclei in native protein structures
UNLABELLED The problem of finding folding nuclei (a set of native contacts that play an important role in folding) along with identifying folding pathways (a time-ordered sequence of folding events) of proteins is one of the most important problems in protein chemistry. Here we propose a novel and simple approach to address this problem as follows: given the topology of the native state, identi...
متن کاملTheoretical perspectives on protein folding.
Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions in the cellular context. Significant advances in theory and experiments have resulted in a conceptual framework for describing the folding mechanisms of globular proteins. The sizes of proteins in the denatured and folded states, cooperativity of the folding transition, dispersions in th...
متن کاملInverse folding of RNA
The aim of the inverse folding problem for RNA is, given a target structure like e.g. the one depicted in Fig. 1, find a sequence that folds into this structure. In this project we will exclusively focus on the secondary structure. The main driving force behind RNA structure formation is the creation of base pairs similar to the ones observed in the DNA double helical structure. In RNA thymine ...
متن کاملAb initio RNA folding.
RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovere...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Entropy
سال: 2015
ISSN: 1099-4300
DOI: 10.3390/e17117827